If you have any questions related to the service Code of Me, read the FAQ (Frequently Asked Questions) below. The answer will be displayed after clicking the selected question. If you do not find an answer that satisfies you, we encourage you to contact our Code of Me experts by e-mail using the contact form you can find here
Reliability and believability of the results of our tests are our priority. That is why at every stage of the working process we make sure that all the information that is passed on to our Clients stems from scientific publications and are in accordance with the newest discoveries in the field of genetics.
The current version of the report uses over 800 publications on the topic of genomic associations, and the included information is based on over 2500 out of hundreds of thousands of proven polymorphisms in the genome. In our analyses, we check only those places in the genome whose impact on a certain disease is scientifically proven. Moreover, we take advantage of the certified laboratory of the company Affymetrix, which is located in the USA, and high-quality sample collection kits provided by the Canadian company Norgen Biotek, which sells its products to many biotechnological firms and laboratories all around the globe.
The method we use is genotyping of the Single Nucleotide Polymorphisms (SNPs) and of the Copy-number variations (CNVs). This approach is commonly used in such studies and its accuracy and repeatability have been verified. To carry out the studies we use the technology devised by Affymetrix, one of the two most prominent companies on the market of genetic variability. The methods used in the Affymetrix laboratory allow to maximize the automation of the process, which has a positive impact on the efficiency of the work and the accuracy of the results. They also allow to analyze several thousands of mutations during one test while using just a single sample of genetic material.
Our courier delivers the kit to the Client in a discreet envelope. It includes everything that is needed to collect a saliva sample at home. The kit consists of: a saliva collection funnel and a collection tube, a collection tube cap, an ampoule with the saliva DNA preservative, an instruction sheet and a reply envelope.
Each collection tube has a unique barcode number, which makes it possible to trace the sample anonymously at every stage of the process.
Norgen’s Saliva DNA Preservative is an aqueous storage buffer designed for rapid cellular lysis and subsequent preservation of DNA from fresh specimens. The buffer prevents the growth of Gram-negative and Gram-positive bacteria and fungi, and also inactivates viruses allowing the resulting non-infectious samples to be handled and shipped safely. In addition, the buffer eliminates the need to immediately process or freeze samples and allows the samples to be shipped to centralized testing facilities at ambient temperature. The components of the buffer allow samples to be stored for more than 5 years without any detectable DNA degradation. The composition of the buffer is patented and registered. If any of the saliva DNA preservative comes into contact with skin or eyes, wash thoroughly with water. Do not ingest the saliva DNA preservative.
Currently, the estimated waiting time is around 2-3 months, which is between 8 and 12 weeks. This is because we have chosen one of the best laboratories in the world to conduct our tests, and it is located in California in the USA. The waiting time includes shipping the sample to the laboratory, processing it, delivering the results and turning the raw data into a clear and accessible report. Additionally, the number of people interested in genetic testing and waiting for their turn to take a test has been growing lately, so the waiting time can be slightly longer.
The use of saliva samples ensures that the whole process is safe, non-invasive and painless. You do not have to go to a laboratory in order for a sample to be collected, as it happens with blood samples. The collection itself is done at home and you can do it on your own without anyone else’s help. Your genetic material is then shipped to the laboratory safely and anonymously in a closed container with a unique barcode.
In order to carry out the test, cells containing DNA are required. The cells from the oral cavity that are present in saliva have exactly the same DNA as every other type of cells that build your body. Thanks to that, the genetic information in blood samples is identical to the information found in saliva samples.
Our Clients’ anonymity and the safety of their personal data is of utmost importance to us. Therefore, in accordance with the contract between Code of Me and our Clients, after the test (genotyping), their genetic material is destroyed in the laboratory.
Diagnostic tests can only confirm or negate whether a person is afflicted with a single disease at the very moment of the test. On the other hand, a test of genetic predispositions is an extensive study which indicates the risk of various diseases. It is a screening which helps gather vast amounts of data from just a single genetic material sample. It helps determine in the case of which diseases there is the biggest probability of developing them. Thanks to that it is possible to implement preventive measures targeted at these particular illnesses.
The result of the test can be influenced by the incorrect way of collecting the sample (saliva), which can lead to the insufficient amount of DNA present in the sample, rendering the genetic test impossible to be carried out. In order to avoid such a situation, while collecting the sample you should follow the instruction very carefully. It is essential that you do not eat or drink anything, smoke or chew gum at least 30 minutes before the collection. Additionally, during that time you should not brush or floss your teeth, and you should also avoid taking any medicine and rinsing your mouth with mouthwash. To collect as many cells as possible, you should move your tongue and rub it against your cheeks to stimulate saliva production. Sometimes in the laboratory it turns out that a small percentage of samples contain less than enough DNA in order to carry out the test. In such a case we send another sample collection kit to the Client.
The shelf life of a saliva sample is 5 years. During that period it can be kept at the temperature between -40 and 30 degrees Celsius. We ensure appropriate conditions for storing and transporting the samples.
The results will be sent to you in the form of a detailed and personalized Report of Genetic Predispositions. You will receive the report in the electronic form and, on the Client’s demand, in printed form. The raw data of the genotyping of polymorphisms obtained in the course of the laboratory study is processed with the help of algorithms and turned into clear and accessible results, which are put in the Code of Me Report. This report is a source of knowledge concerning a person’s unique DNA code. It includes information about possible risks and benefits stemming from the possessed set of genes.
The report sent to a Client includes data about his or her individual predispositions in several genetically conditioned areas, among others those concerning the risk of developing several dozens of various diseases and tumors. We do our best to put as much useful information as possible in the report, choosing it on the basis of the contact with our Clients. In order to facilitate the understanding and interpretation of the information incorporated in the report, the results are presented in textual form and are accompanied by a chart, which clearly illustrates the comparison between the individual’s result and the average result of the population. We make sure to provide our Clients only with information that is easily understandable and useful from the point of view of a person who wants to take good care of his or her health.
A genetic risk increases the chance of developing an illness, so people with a higher risk should be especially careful and avoid environmental risk factor. For example, a person with a higher risk of lung cancer should avoid inhaling cigarette smoke. It is also advised that in case of establishing a genetic predisposition to a disease, you should inform your physician about the results and ask him or her if, basing on this information, he or she sees a need for more detailed diagnostic tests.
A Single Nucleotide Polymorphism, or a genetic marker or SNP, is a polymorphism of a single base in the genetic code. It can also be, among others, a single nucleotide change causing differences in the gene expression or the structure of its protein, or the features thereof. Genetic polymorphisms result from hereditary DNA mutations. Point mutations caused by the exchange of a single pair of bases for a different one are one of the most frequent genetic variations. The prevalence of different variants for particular genes varies between different ethnic groups.